New world, but not Old World, monkeys carry several genes encoding beta-microseminoprotein
Author
Summary, in English
It was shown by Southern hybridization that cotton-top tamarin and common marmoset, New World monkeys, carry three or more genes encoding beta-microseminoprotein, also known as PSP94. In contrast, the genomes of Old World monkeys, as represented by rhesus macaque and sacred baboon, contain a single gene. Clones containing three different genes encoding beta-microseminoprotein were isolated from a cotton-top tamarin genomic library. They carry two complete genes of four exons and a third gene lacking the first exon. The structure suggests that the three genes are functionally active and give rise to transcripts that are approximately 86% similar in sequence. By sequencing one gene in full, it was shown that the introns carry an excess of interspersed repeats, on average 29% of the introns consist of Alu repeats. A phylogenetic analysis demonstrated that the genes probably arose in New World monkeys after the separation from Old World primates.
Department/s
Publishing year
1999
Language
English
Pages
407-414
Publication/Series
European Journal of Biochemistry
Volume
264
Issue
2
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Medicinal Chemistry
Keywords
- mucous
- evolution
- prostate
- semen
Status
Published
Research group
- Clinical Chemistry, Malmö
ISBN/ISSN/Other
- ISSN: 0014-2956