Peptidyl diazomethylketones as cysteine protease inhibitors structurally based upon the inhibitory centers of cystatins

Summary, in English

Six new putative cysteine protease inhibitors based upon sequences of the N-terminal binding fragments of rat cystatin A, bovine cystatin C and human cystatins D and S were synthesized, inhibitory activities of these compounds against papain and bovine cathepsin B were tested. Additionally, agar well diffusion test of their antibacterial activity against Streptococcus pyogenes was performed.

• Author: F. Kasprzykowski; R. Kasprzykowska; P. Kania; K. Plucinska; Anders Grubb; Magnus Abrahamson; C. Schalen
• Department/s: Division of Clinical Chemistry and Pharmacology
• Publishing year: 2001
• Language: English
• Pages: 831-837
• Publication/Series: Polish Journal of Chemistry
• Volume: 75
• Issue: 6
• Document type: Journal article
• Publisher: Polish Chemical Society
• Topic: Pharmacology and Toxicology; Medicinal Chemistry
• Status: Published
• ISBN/ISSN/Other: ISSN: 0137-5083