Long-term course of Mycobacterium tuberculosis infection in Swedish birth cohorts during the twentieth century.
Author
Summary, in English
Abstract
SETTING:
Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.
OBJECTIVE:
To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.
DESIGN:
Time trend analysis on TB incidence using age-cohort modelling.
RESULTS:
The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a level between 9.8% and 10.7%. The reactivation rate of latent TB infection (LTBI) was 2% after 1967, when indigenous transmission had disappeared.
CONCLUSION:
Although approximately 10% of persons with LTBI developed active TB, the majority of cases occurred shortly after infection, and the rates of reactivation declined over time. This indicates extensive spontaneous clearance of LTBI
SETTING:
Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.
OBJECTIVE:
To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.
DESIGN:
Time trend analysis on TB incidence using age-cohort modelling.
RESULTS:
The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a level between 9.8% and 10.7%. The reactivation rate of latent TB infection (LTBI) was 2% after 1967, when indigenous transmission had disappeared.
CONCLUSION:
Although approximately 10% of persons with LTBI developed active TB, the majority of cases occurred shortly after infection, and the rates of reactivation declined over time. This indicates extensive spontaneous clearance of LTBI
Department/s
- Infectious Diseases Research Unit
- Division of Occupational and Environmental Medicine, Lund University
- Division of Medical Microbiology
- EpiHealth: Epidemiology for Health
Publishing year
2011
Language
English
Pages
736-740
Publication/Series
The International Journal of Tuberculosis and Lung Disease
Volume
15
Issue
6
Links
Document type
Journal article
Publisher
International Union against Tuberculosis and Lung Disease
Topic
- Respiratory Medicine and Allergy
Status
Published
Research group
- Infectious Diseases Research Unit
ISBN/ISSN/Other
- ISSN: 1815-7920