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Use of ENCODE Resources to Characterize Novel Proteoforms and Missing Proteins in the Human Proteome

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Author

  • Carol Nilsson
  • Ekaterina Mostovenko
  • Cheryl Lichti
  • Kelly Ruggles
  • David Fenyö
  • Kate Rosenbloom
  • William Hancock
  • Young-Ki Paik
  • Gilbert Omenn
  • Joshua LaBaer
  • Roger Kroes
  • Mathias Uhlén
  • Sophia Hober
  • Ákos Végvári
  • Per Andrén
  • Erik Sulman
  • Frederick Lang
  • Manuel Fuentes
  • Elisabet Carlsohn
  • Mark Emmett
  • Joseph Moskal
  • Frode Berven
  • Thomas Fehniger
  • György Marko-Varga
Show all

Summary, in English

We describe integrated strategies that employ both translation of ENCODE data and major proteomic technology pillars to improve the identification of the missing proteins, protein isoforms, and PTMs. The results from proteoENCODEdb searches with experimental mass spectral data indicate that some novel splice forms detected at the transcript level are in fact translated to proteins. Our results provide a step toward the directives of the C-HPP initiative and related biomedical research.

Publishing year

2015

Language

English

Pages

603-608

Publication/Series

Journal of Proteome Research

Volume

14

Issue

2

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Medical Engineering

Keywords

  • Glioma stem cell
  • ENCODE
  • Chromosome-centric Human Protein Project
  • Protein sequence mass spectrometry
  • Microassays
  • Missing proteins

Status

Published

ISBN/ISSN/Other

  • ISSN: 1535-3893