Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Summary, in English

The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.

• Author: Hedvig Bennet; Ines Mollet; Alexander Balhuizen; Anya Medina Benavente; Cecilia Nagorny; Annika Bagge; Joao Fadista; Emilia Ottosson Laakso; Petter Vikman; Marloes Dekker Nitert; Lena Eliasson; Nils Wierup; Isabella Artner; Malin Fex
• Department/s: Celiac Disease and Diabetes Unit; Diabetes - Islet Cell Exocytosis; Diabetes - Molecular Metabolism; Translational Muscle Research; Neuroendocrine Cell Biology; Stem Cell Center; EXODIAB: Excellence of Diabetes Research in Sweden; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
• Publishing year: 2016-01-06
• Language: English
• Pages: 744-754
• Publication/Series: Diabetologia
• Volume: 59
• Issue: 4
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26733006?dopt=Abstract; http://dx.doi.org/10.1007/s00125-015-3847-6
• Document type: Journal article
• Publisher: Springer
• Topic: Endocrinology and Diabetes
• Status: Published
• Research group: Celiac Disease and Diabetes Unit; Diabetes - Islet Cell Exocytosis; Diabetes - Molecular Metabolism; Genomics, Diabetes and Endocrinology; Neuroendocrine Cell Biology
• ISBN/ISSN/Other: ISSN: 1432-0428