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3-Hydroxy fatty acids in saliva as diagnostic markers in chronic periodontitis

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Author

Summary, in English

Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA analysis in diagnosing peridontitis were, respectively, 0.92, 1.00, 1.00, and 0.90. The results indicate that 3-OH FA analysis of saliva samples is a useful diagnostic method in chronic periodontitis.

Publishing year

2005

Language

English

Pages

285-291

Publication/Series

Journal of Microbiological Methods

Volume

62

Issue

3

Document type

Journal article

Publisher

Elsevier

Topic

  • Microbiology in the medical area

Keywords

  • gas chronnatography-mass spectrometry
  • acids
  • anaerobic gram-negative bacteria/periodontal pathogens
  • 3-hydroxy fatty
  • periodontitis/etiology
  • microbial chemical
  • inarkers

Status

Published

ISBN/ISSN/Other

  • ISSN: 1872-8359