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Feeding strategies for E-coli fermentations demanding an enriched environment

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Author

Summary, in English

The addition of a carbon nutrient feed to a fed-batch cultivation is often not enough to obtain satisfactory growth and/or production. In some cases, an additional feed with for example supplementary amino acids or complex media is required. This work presents the development of feeding strategies where more than one feed is required and the knowledge of the growth requirements is low. Simulations and cultivations with E. coli are shown using the proposed feed controllers which are based on a probing control concept. The strategies work well and they can be used to shorten the process development phase considerably.

Publishing year

2007

Language

English

Pages

13-25

Publication/Series

Bioprocess and Biosystems Engineering

Volume

30

Issue

1

Document type

Journal article

Publisher

Springer

Topic

  • Control Engineering

Keywords

  • Escherichia coli
  • complex medium
  • amino acid
  • fed-batch cultivation
  • fermentation process
  • feeding strategy

Status

Published

ISBN/ISSN/Other

  • ISSN: 1615-7605