Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother
Author
Summary, in English
BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).
MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.
RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).
CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.
Department/s
Publishing year
1998
Language
English
Pages
145-148
Publication/Series
Vox Sanguinis
Volume
75
Issue
2
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Cancer and Oncology
Keywords
- Adult
- Blood Transfusion
- Case-Control Studies
- Cohort Studies
- Delivery, Obstetric
- Female
- Hodgkin Disease
- Humans
- Incidence
- Lymphoma, Non-Hodgkin
- Postpartum Hemorrhage
- Pregnancy
- Risk Factors
- Sweden
Status
Published
Research group
- Lund Melanoma Study Group
ISBN/ISSN/Other
- ISSN: 0042-9007