Striatal Atrophy in the Behavioural Variant of Frontotemporal Dementia: Correlation with Diagnosis, Negative Symptoms and Disease Severity.

Summary, in English

Behavioural variant frontotemporal dementia (bvFTD) is associated with changes in dorsal striatal parts of the basal ganglia (caudate nucleus and putamen), related to dysfunction in the cortico-striato-thalamic circuits which help mediate executive and motor functions. We aimed to determine whether the size and shape of striatal structures correlated with diagnosis of bvFTD, and measures of clinical severity, behaviour and cognition.

• Author: Matthew D Macfarlane; David Jakabek; Mark Walterfang; Susanna Vestberg; Dennis Velakoulis; Fiona A Wilkes; Christer Nilsson; Danielle van Westen; Jeffrey C L Looi; Alexander Santillo
• Department/s: MultiPark: Multidisciplinary research focused on Parkinson´s disease; Psychiatry (Lund); Department of Psychology; Clinical Memory Research; Neuroradiology; Diagnostic Radiology, (Lund)
• Publishing year: 2015
• Language: English
• Publication/Series: PLoS ONE
• Volume: 10
• Issue: 6
• Full text: - 2 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26075893?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0129692
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Neurology
• Status: Published
• Research group: Clinical Memory Research; Neuroradiology
• ISBN/ISSN/Other: ISSN: 1932-6203