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Sensitivity of mongolian gerbils to trichloroethylene exposure during neonatal growth

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Author

Summary, in English

Continuous exposure of young mongolian gerbils to trichloroethylene (230 ppm) was started at different times during the first month of life. The onset of exposure was accompanied by an increased number of deaths among the pups and by an immediate reduction in growth rate. The proportion of dead pups was greatest when exposure was started at birth, and decreased rapidly with increasing age at onset of exposure. Growth rate was partially restored approx. 1 week after the onset of exposure. After weaning the effect of the exposure on growth decreased, and the variation in the effect among different litters was considerably reduced. The enhanced sensitivity of the pups to trichloroethylene (TCE) exposure is believed to be due to a disturbance in the mother-offspring relationship.

Publishing year

1982

Language

English

Pages

97-101

Publication/Series

Toxicology Letters

Volume

14

Issue

1-2

Document type

Journal article

Publisher

Elsevier

Topic

  • Probability Theory and Statistics

Keywords

  • Mongolian gerbil
  • trichloroethylene
  • Meriones unguiculatus
  • neonatal
  • growth

Status

Published

ISBN/ISSN/Other

  • ISSN: 1879-3169