Progression of retinopathy in insulin-treated type 2 diabetic patients.
Author
Summary, in English
OBJECTIVE—To study the progression of retinopathy 3 years after initiation of insulin therapy.
RESEARCH DESIGN AND METHODS—In a prospective, observational case-control study, 42 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, 24, and 36 months after change to insulin therapy. Retinopathy was graded based on fundus photographs using the Wisconsin scale; HbA1c and IGF-1 were measured.
RESULTS—During the observation period of 3 years, 26 patients progressed in the retinopathy scale; 11 patients progressed at least three levels. After 3 years of insulin therapy, HbA1c and IGF-1 were significantly lower than at baseline. Progression of retinopathy greater than or equal to three levels was related to high IGF-1 levels.
CONCLUSIONS—A relationship was found between high IGF-1 levels at 3 years and progression of retinopathy in type 2 diabetic patients.
RESEARCH DESIGN AND METHODS—In a prospective, observational case-control study, 42 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, 24, and 36 months after change to insulin therapy. Retinopathy was graded based on fundus photographs using the Wisconsin scale; HbA1c and IGF-1 were measured.
RESULTS—During the observation period of 3 years, 26 patients progressed in the retinopathy scale; 11 patients progressed at least three levels. After 3 years of insulin therapy, HbA1c and IGF-1 were significantly lower than at baseline. Progression of retinopathy greater than or equal to three levels was related to high IGF-1 levels.
CONCLUSIONS—A relationship was found between high IGF-1 levels at 3 years and progression of retinopathy in type 2 diabetic patients.
Department/s
Publishing year
2002
Language
English
Pages
381-385
Publication/Series
Diabetes Care
Volume
25
Issue
2
Links
Document type
Journal article
Publisher
American Diabetes Association
Topic
- Endocrinology and Diabetes
Keywords
- Treatment Outcome
- Non-U.S. Gov't
- Support
- Prospective Studies
- Middle Age
- Non-Insulin-Dependent: physiopathology
- Diabetic Retinopathy: physiopathology
- Disease Progression
- Logistic Models
- Insulin: administration & dosage
- Hypoglycemic Agents: administration & dosage
- Human
- Follow-Up Studies
- Male
- Female
- Non-Insulin-Dependent: drug therapy
- Diabetes Mellitus
- Non-Insulin-Dependent: complications
- Aged
- Case-Control Studies
Status
Published
Research group
- Ophthalmology (Malmö)
- Genomics, Diabetes and Endocrinology
- Clinical Chemistry, Malmö
ISBN/ISSN/Other
- ISSN: 1935-5548