Identification of an insertion sequence located in a region encoding virulence factors of Streptococcus pyogenes

Summary, in English

An insertion sequence, IS1562, was identified in a Streptococcus pyogenes strain of the clinically important M1 serotype. IS1562 is located in the mga regulon between the genes coding for the M protein and the C5a peptidase, both important virulence factors. The same or similar insertion sequences were found in most S. pyogenes strains, but the chromosomal location differed among isolates.

• Author: Andreas Berge; Magnus Rasmussen; Lars Björck
• Department/s: Infection Medicine (BMC)
• Publishing year: 1998
• Language: English
• Pages: 3449-3453
• Publication/Series: Infection and Immunity
• Volume: 66
• Issue: 7
• Links: http://iai.highwire.org/cgi/content/full/66/7/3449
• Document type: Journal article
• Publisher: American Society for Microbiology
• Topic: Infectious Medicine
• Status: Published
• ISBN/ISSN/Other: ISSN: 1098-5522