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Multimodal approach to assess tumour vasculature and potential treatment effect with DCE-US and DCE-MRI quantification in CWR22 prostate tumour xenografts.

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Author

  • N Arteaga-Marrero
  • C B Rygh
  • J F Mainou-Gomez
  • K Nylund
  • D Roehrich
  • J Heggdal
  • P Matulaniec
  • O H Gilja
  • R K Reed
  • Lena M Svensson
  • Nataliya Lutay
  • D R Olsen
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Summary, in English

The aim of this study was to compare intratumoural heterogeneity and longitudinal changes assessed by dynamic contrast-enhanced ultrasound (DCE-US) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in prostate tumour xenografts. In vivo DCE-US and DCE-MRI were obtained 24 h pre- (day 0) and post- (day 2) radiation treatment with a single dose of 7.5 Gy. Characterization of the tumour vasculature was determined by Brix pharmacokinetic analysis of the time-intensity curves. Histogram analysis of voxels showed significant changes (p < 0.001) from day 0 to day 2 in both modalities for kep , the exchange rate constant from the extracellular extravascular space to the plasma, and kel , the elimination rate constant of the contrast. In addition, kep and kel values from DCE-US were significantly higher than those derived from DCE-MRI at day 0 (p < 0.0001) for both groups. At day 2, kel followed the same tendency for both groups, whereas kep showed this tendency only for the treated group in intermediate-enhancement regions. Regarding kep median values, longitudinal changes were not found for any modality. However, at day 2, kep linked to DCE-US was correlated to MVD in high-enhancement areas for the treated group (p = 0.05). In contrast, correlation to necrosis was detected for the control group in intermediate-enhancement areas (p < 0.1). Intratumoural heterogeneity and longitudinal changes in tumour vasculature were assessed for both modalities. Microvascular parameters derived from DCE-US seem to provide reliable biomarkers during radiotherapy as validated by histology. Furthermore, DCE-US could be a stand-alone or a complementary technique. Copyright © 2015 John Wiley & Sons, Ltd.

Department/s

Publishing year

2015

Language

English

Pages

428-437

Publication/Series

Contrast Media & Molecular Imaging

Volume

10

Issue

6

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Research group

  • Leukocyte Migration

ISBN/ISSN/Other

  • ISSN: 1555-4317