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JAK/STAT Signalling in Huntington's Disease Immune Cells.

På svenska

Author

  • Ulrike Träger
  • Anna Magnusson-Lind
  • Nayana Lahiri Swales
  • Edward Wild
  • Janet North
  • Mark Lowdell
  • Maria Björkqvist

Summary, in English

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Both central and peripheral innate immune activation have been described as features of the disease. Isolated human HD monocytes have been shown to produce more cytokines upon LPS stimulation compared to control monocytes. Understanding alterations in the signalling cascades responsible and activated by this increase in pro-inflammatory cytokine production is crucial in understanding the molecular basis of this phenomenon. Here we investigated the signalling cascade most commonly activated by pro-inflammatory cytokines such as IL-6 - the JAK/STAT signalling cascade. Using flow cytometry, we show that one out of three key transcription factors activated by JAK/STAT signalling is altered in primary human HD innate immune cells, suggesting that this pathway may only play a minor, additive role in the immune cell dysfunction in HD.

Publishing year

2013-12-13

Language

English

Publication/Series

PLoS Currents

Volume

5

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Neurosciences

Status

Published

Research group

  • Biomarkers in Brain Disease

ISBN/ISSN/Other

  • ISSN: 2157-3999