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Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

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Author

  • Caroline Wigerup
  • Ingrid Øra
  • Cecilia Brunhoff
  • Lola Anagnostaki
  • Göran Landberg
  • Jenny L Persson

Summary, in English

A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.

Publishing year

2006

Language

English

Pages

254-261

Publication/Series

Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

Volume

30

Issue

3

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Keywords

  • cyclin A1
  • cyclin dependent kinase
  • event
  • acute lymphoblastic leukemia
  • free survival
  • cell cycle
  • disease characteristics

Status

Published

Research group

  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1873-5835