Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems.
Author
Summary, in English
The time required for the design of a new delivery device can be sensibly reduced if the release mechanism is understood and an appropriate mathematical model is used to characterize the system. Once all the model parameters are obtained, in silico experiments can be performed, to provide estimates of the release from devices with different geometries and compositions. In this review coated and matrix systems are considered. For coated formulations, models describing the diffusional drug release, the osmotic pumping drug release, and the lag phase of pellets undergoing cracking in the coating due to the build-up of a hydrostatic pressure are reviewed. For matrix systems, models describing pure polymer dissolution, diffusion in the polymer and drug release from swelling and eroding polymer matrix formulations are reviewed. Importantly, the experiments used to characterize the processes occurring during the release and to validate the models are presented and discussed.
Department/s
Publishing year
2011
Language
English
Pages
54-77
Publication/Series
International Journal of Pharmaceutics
Volume
418
Document type
Journal article
Publisher
Elsevier
Topic
- Chemical Engineering
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-3476