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Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models

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Author

Summary, in English

The tumor oxygenation status associates with aggressive behavior. Oxygen shortage, hypoxia, is a major driving force behind tumor vascularization, and hypoxia enhances mutational rate, metastatic spread, and resistance to radiation and chemotherapy. We recently discovered that hypoxia promotes dedifferentiation of neuroblastoma and breast carcinoma cells and development of stem cell-like features. In both these tumor forms there is a correlation between low differentiation stage and poor outcome, and we conclude that the dedifferentiating effect of lowered oxygen adds to the aggressive phenotype induced by hypoxia. With neuroblastoma and breast carcinoma as human tumor model systems, we have addressed questions related to hypoxia-induced molecular mechanisms governing malignant behavior of tumor cells, with emphasis on differentiation and growth control. By global gene expression analyses we are currently screening for gene products exclusively expressed or modified in hypoxic cells with the aim to use them as targets for treatment.

Publishing year

2006

Language

English

Pages

179-193

Publication/Series

Advances in experimental medicine and biology

Volume

587

Document type

Conference paper

Publisher

Springer

Topic

  • Cancer and Oncology

Keywords

  • Animals
  • Anoxia
  • Breast Neoplasms
  • Cell Differentiation
  • Gene Expression Regulation
  • Neoplastic
  • Humans
  • Neuroblastoma
  • Phenotype

Status

Published

ISBN/ISSN/Other

  • ISSN: 0065-2598