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Neocortical grafts placed in the infarcted brain of adult rats: few or no efferent fibers grow from transplant to host

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Author

  • Martin Grabowski
  • Barbro Johansson
  • Patrik Brundin

Summary, in English

The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal rat cortical grafts to form connections with host neural circuitries after an ischemic insult.

Publishing year

1995

Language

English

Pages

273-276

Publication/Series

Experimental Neurology

Volume

134

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Neurology

Status

Published

ISBN/ISSN/Other

  • ISSN: 0014-4886