Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization

Summary, in English

In this paper, we present the development of a new potential blood pool contrast agent for magnetic resonance imaging applications (MRA/MRI) based on gadolinium complexes containing amphiphilic supramolecular aggregates. A novel amphiphilic unimer, containing the DTPAGlu chelating agent covalently bound to two C18 alkylic chains, has been synthesized. DTPAGlu is a well-known chelating agent for a wide number of ions such as the paramagnetic metal ion Gd3+ used as contrast agent in MRA/MRI. The wide aggregation behavior of this surfactant, as free base or as gadolinium complex, has been studied and compared by means of dynamic light scattering, small-angle neutron scattering and cryogenic transmission electron microscopy techniques. Near neutral pH in both cases, the dominant aggregates are micelles. The high negative actual charge of the surfactant headgroup causes a strong headgroups repulsion, promoting the formation of large and high curvature aggregates. By decreasing pH and less markedly increasing the ionic strength, we observe a micelle-to-vesicle transition driven by a decreased electrostatic repulsion. A straightforward switch between different aggregation states can be particularly useful in the development of pH-responsive MRA/MRI contrast agents.

• Author: Mauro Vaccaro; Antonella Accardo; Diego Tesauro; Gaetano Mangiapia; David Löf; Karin Schillén; Olle Söderman; Giancarlo Morelli; Luigi Paduano
• Department/s: Physical Chemistry
• Publishing year: 2006
• Language: English
• Pages: 6635-6643
• Publication/Series: Langmuir
• Volume: 22
• Issue: 15
• Links: http://dx.doi.org/10.1021/la053500k
• Document type: Journal article
• Publisher: The American Chemical Society (ACS)
• Topic: Physical Chemistry
• Status: Published
• ISBN/ISSN/Other: ISSN: 0743-7463