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Morphological detection of neurogenic muscle disorders: how can statistical methods aid diagnosis?

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Author

Summary, in English

The light microscopical observation of groups of histochemically similar muscle fibres, referred to as fibre-type grouping, is commonly considered to be evidence of a denervation and reinnervation process affecting the spinal motor neurons or the peripheral nerves. It can be difficult to assess whether such groups have occurred by chance or are due to a slowly progressive pathological process in an early stage of development. Consequently, there is a need for one or more objective methods for assessing the fibre-type arrangement in healthy and diseased human muscles. The purposes here are to review the methods for the detection of fibre-type grouping that have been published in the last two decades, to describe some unsolved problems, and to indicate some likely lines of development.

Publishing year

1987

Language

English

Pages

109-115

Publication/Series

Acta Neuropathologica

Volume

75

Issue

2

Document type

Journal article

Publisher

Springer

Topic

  • Neurosciences

Keywords

  • Nerve degeneration
  • Muscular atrophy
  • Muscle denervation
  • Histocytochemistry
  • Aging

Status

Published

ISBN/ISSN/Other

  • ISSN: 1432-0533