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Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors

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Author

Summary, in English

PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.

METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.

RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.

CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.

Publishing year

2009-02

Language

English

Pages

40-133

Publication/Series

International Journal of Cardiovascular Imaging

Volume

25

Issue

2

Document type

Journal article

Publisher

Springer

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Atherosclerosis
  • Cardiovascular Diseases
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiopharmaceuticals
  • Risk Factors
  • Tomography, X-Ray Computed
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

ISBN/ISSN/Other

  • ISSN: 1875-8312