Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation.

Summary, in English

Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association between cystatin C level and inflammation stem from large cohort studies. The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation, who undergo elective surgery. Methods. Cystatin C, creatinine, and the inflammatory markers CRP, serum amyloid A (SAA), haptoglobin and orosomucoid were measured in plasma samples from 35 patients the day before elective surgery and subsequently during seven consecutive days. Results. Twenty patients had CRP-levels below 1 mg/L before surgery and low levels of the additional inflammatory markers. Surgery caused marked inflammation with high peak values of CRP and SAA on the second day after the operation. The cystatin C level did not change significantly during the observation period and did not correlate significantly with the level of any of the four inflammatory markers. The creatinine level was significantly reduced on the first postoperative day but reached the preoperative level towards the end of the observation period. Conclusion. The inflammatory status of a patient does not influence the role of cystatin C as a marker of successful aging, nor of GFR.

• Author: Anders Grubb; Jonas Björk; Ulf Nyman; Joanna Pollak; Johan Bengzon; Gustav Östner; Veronica Lindström
• Department/s: Division of Clinical Chemistry and Pharmacology; Division of Occupational and Environmental Medicine, Lund University; Radiology Diagnostics, Malmö; Neurosurgery; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; EpiHealth: Epidemiology for Health
• Publishing year: 2011
• Language: English
• Pages: 145-149
• Publication/Series: Scandinavian Journal of Clinical and Laboratory Investigation
• Volume: 71
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21198422?dopt=Abstract; http://dx.doi.org/10.3109/00365513.2010.546879
• Document type: Journal article
• Publisher: Informa Healthcare
• Topic: Environmental Health and Occupational Health; Pharmacology and Toxicology; Neurology; Surgery; Radiology, Nuclear Medicine and Medical Imaging; Medicinal Chemistry
• Status: Published
• Research group: Radiology Diagnostics, Malmö
• ISBN/ISSN/Other: ISSN: 1502-7686