Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.

Summary, in English

Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent-TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain.

• Author: Miguel Burguillos Garcia; Martina Svensson; Tim Schulte; Antonio Boza Serrano; Albert Garcia-Quintanilla; Edel Kavanagh; Martiniano Santiago; Nikenza Viceconte; Maria Jose Oliva-Martin; Ahmed Mohamed Osman; Emma Salomonsson; Lahouari Amar; Annette Persson; Klas Blomgren; Adnane Achour; Elisabet Englund; Hakon Leffler; Jose Luis Venero; Bertrand Joseph; Tomas Deierborg
• Department/s: Department of Experimental Medical Science; Neuroinflammation; Division of Microbiology, Immunology and Glycobiology - MIG; Tumor microenvironment; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2015
• Language: English
• Pages: 1626-1638
• Publication/Series: Cell Reports
• Volume: 10
• Issue: 9
• Full text: - 4 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25753426?dopt=Abstract; http://dx.doi.org/10.1016/j.celrep.2015.02.012
• Document type: Journal article
• Publisher: Cell Press
• Topic: Cell Biology
• Status: Published
• Research group: Neuroinflammation
• ISBN/ISSN/Other: ISSN: 2211-1247