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Breastfeeding does not influence the development of inhibitors in haemophilia.

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Author

  • Karin Knobe
  • Lilian Tengborn
  • P Petrini
  • Rolf Ljung

Summary, in English

Our aim was to test the hypothesis that breastfeeding may reduce development of inhibitors in male infants with haemophilia by inducing an oral immune tolerance to factor VIII. To achieve that goal, we performed a structured epidemiological survey comprising all males born with severe haemophilia A (in all 100 patients, 19 with inhibitors) or haemophilia B (in all 16 patients, six with inhibitors) in Sweden in 1980-99. Our results show no protective effect of breastfeeding.

Department/s

Publishing year

2002

Language

English

Pages

657-659

Publication/Series

Haemophilia

Volume

8

Issue

5

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Hematology

Keywords

  • Immune Tolerance
  • Hemophilia A: immunology
  • Hemophilia B: immunology
  • Human
  • Preschool
  • Factor VIII: metabolism
  • Infant
  • Newborn
  • Male
  • Sweden
  • Autoantibodies: blood
  • Blood Coagulation Factor Inhibitors: metabolism
  • Breast Feeding
  • Child

Status

Published

Research group

  • Paediatric Hematologic Research Group
  • Paediatric Haematology Research Unit

ISBN/ISSN/Other

  • ISSN: 1351-8216