Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability.

Summary, in English

High levels of the antimicrobial peptide, LL-37, are detected in gingival crevicular fluid from patients with chronic periodontitis. LL-37 not only shows antimicrobial activity but also affects host-cell viability. The objective of the present study was to identify endogenous mechanisms that antagonize the detrimental effects of LL-37 on osteoblast viability, focusing on the human peptide p33 expressed on the surface of various cell types.

• Author: Daniel Svensson; Johannes Westman; Claes Wickström; Daniel Jönsson; Heiko Herwald; Bengt-Olof Nilsson
• Department/s: Vascular Physiology; Infection Medicine (BMC); Department of Experimental Medical Science
• Publishing year: 2015
• Language: English
• Pages: 80-88
• Publication/Series: Journal of Periodontal Research
• Volume: 50
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24697598?dopt=Abstract; http://dx.doi.org/10.1111/jre.12184
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Dentistry
• Status: Published
• Project: Effects of the antimicrobial peptide LL-37 on host cell viability
• Research group: Vascular Physiology
• ISBN/ISSN/Other: ISSN: 1600-0765