Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis.

Summary, in English

Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled.

• Author: Stine A Danielsen; Guro E Lind; Matthias Kolberg; Maren Høland; Bodil Bjerkehagen; Kirsten Sundby Hall; Eva van den Berg; Fredrik Mertens; Sigbjørn Smeland; Piero Picci; Ragnhild A Lothe
• Department/s: Division of Clinical Genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015
• Language: English
• Pages: 63-69
• Publication/Series: Neuro-Oncology
• Volume: 17
• Issue: 1
• Full text: - 212 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25038505?dopt=Abstract; http://dx.doi.org/10.1093/neuonc/nou140
• Document type: Journal article
• Publisher: Oxford University Press
• Topic: Medical Genetics
• Status: Published
• ISBN/ISSN/Other: ISSN: 1523-5866