Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics

Summary, in English

Chondroid lipoma is a rare, benign tumor that may mimic soft-tissue sarcoma clinically. Its histopathologic features may resemble hibernoma, myxoid liposarcoma, myxoid chondrosarcoma, and other lipomatous or chondroid neoplasms. In this study, a chondroid lipoma was analyzed by fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and metaphase fluorescence in situ hybridization. The results demonstrate that chondroid lipoma exhibits a characteristic pattern by fine-needle aspiration cytology, including a mixture of benign adipose tissue with lipoblastlike cells, and chondroblastlike cells with a fibrochondroid matrix. Cytogenetically, a three-way rearrangement between chromosomes 1, 2, and 5 was found, together with an 11;16 translocation with a breakpoint in 11q13, approximately 1 Mb proximal to the MEN1 region shown to be rearranged frequently in hibernoma. The presence of a karyotype of low complexity, but without any of the genetic aberrations characteristic for other types of soft-tissue tumors, indicate that chondroid lipoma develops along a unique pathogenetic pathway.

• Author: David Gisselsson Nord; Henryk Domanski; Mattias Höglund; Birgitta Carlén; Fredrik Mertens; Helena Willen; Nils Mandahl
• Department/s: Division of Clinical Genetics; Tumor microenvironment
• Publishing year: 1999
• Language: English
• Pages: 1300-1300
• Publication/Series: American Journal of Surgical Pathology
• Volume: 23
• Issue: 10
• Document type: Journal article
• Publisher: Lippincott Williams & Wilkins
• Topic: Surgery
• Status: Published
• ISBN/ISSN/Other: ISSN: 1532-0979