Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast cancer cells.

Summary, in English

Regulation of mRNAs is one way to control protein levels and thereby important cellular processes such as growth, invasion and apoptosis. G3BPs constitute a family of mRNA-binding proteins, shown to be overexpressed in several cancer types, including breast, colon and pancreas cancer. G3BP has been reported to both stabilize and induce degradation of specific mRNAs.

• Author: Sofia Winslow; Karin Leandersson; Christer Larsson
• Department/s: Department of Translational Medicine; Experimental Pathology, Malmö; Cancer Immunology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2013
• Language: English
• Publication/Series: Molecular Cancer
• Volume: 12
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24321297?dopt=Abstract; http://dx.doi.org/10.1186/1476-4598-12-156
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Cancer and Oncology
• Status: Published
• Research group: Experimental Pathology, Malmö; Cancer Immunology, Malmö
• ISBN/ISSN/Other: ISSN: 1476-4598