The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

α-Synuclein: The Long Distance Runner.

På svenska

Author

  • Sonia George
  • Nolwen Rey
  • Nicole Reichenbach
  • Jennifer Steiner
  • Patrik Brundin

Summary, in English

Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.

Publishing year

2013

Language

English

Pages

350-357

Publication/Series

Brain Pathology

Volume

23

Issue

3

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Neurosciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 1750-3639