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In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light

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Author

  • C af Klinteberg
  • A Pifferi
  • Stefan Andersson-Engels
  • R Cubeddu
  • Sune Svanberg

Summary, in English

A system based on a femtosecond white-light continuum and a streak camera was used for recordings of the in vivo absorption spectra of the tumor-seeking agent disulphonated aluminum phthalocyanine. Measurements for different drug doses were performed on tumor tissue (muscle-implanted adenocarcinoma) and normal muscle tissue in rats. It was found that the shape of the spectrum is tissue dependent. The peak of the absorption spectrum is blueshifted in tumor tissue as compared with the muscle. Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength.

Department/s

Publishing year

2005

Language

English

Pages

2213-2220

Publication/Series

Applied Optics

Volume

44

Issue

11

Document type

Journal article

Publisher

Optical Society of America

Topic

  • Atom and Molecular Physics and Optics

Status

Published

ISBN/ISSN/Other

  • ISSN: 2155-3165