The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling.

På svenska

Author

Summary, in English

The transforming growth factor (TGF)-beta superfamily of growth factors, including the TGF-betas, activins, and bone morphogenetic proteins (BMPs), provide cells with a broad spectrum of regulatory signals through the intracellular Smad pathway. Since loss-of-function studies of a majority of the TGF-beta superfamily members result in embryonic lethality, much of our current knowledge of the TGF-beta superfamily's role in hematopoiesis is generated from studies performed in vitro, or in very early stages of embryonic development. TGF-beta is well documented as a potent inhibitor of hematopoietic stem cell (HSC) proliferation in vitro, while its role in vivo is largely unknown. BMP signaling is crucial for the initiation of hematopoiesis in the developing embryo, although its role in adult hematopoiesis remains elusive. More recently we and others have used conditional knockout models to unravel the role of several components of TGF-beta family signaling in adult hematopoiesis. Here we review the currently known functions for the major factors of this signaling family in embryonic and adult hematopoietic regulation and discuss the context dependency and complexity that permeate this regulation.

Publishing year

2009

Language

English

Pages

55-69

Publication/Series

Annals of the New York Academy of Sciences

Volume

1176

Document type

Journal article review

Publisher

Wiley-Blackwell

Topic

  • Hematology

Keywords

  • Transforming Growth Factor beta: physiology
  • Smad Proteins: metabolism
  • Smad Proteins: genetics
  • Hematopoietic Stem Cells: physiology
  • Hematopoiesis: genetics
  • Hematopoietic Stem Cells: metabolism

Status

Published

Research group

  • Stem cell and red cell biology

ISBN/ISSN/Other

  • ISSN: 0077-8923