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Gelatin/glycerol coating to preserve mechanically compliant nanowire electrodes from damage during brain implantation

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Author

Summary, in English

Chronically implanted neural implants are of clinical importance. However, currently used electrodes have several drawbacks. Some weeks after implantation in the brain, a glial scar forms around the electrode, causing decreased electrode functionality. Nanostructures, and in particular nanowires, are good candidates to overcome these drawbacks and reduce glial scar formation. Using a mechanically compliant substrate with protruding nanowires could further decrease the glial scar formation by reducing the mechanical mismatch between the tissue and the electrode. However, flexible substrates require strengthening upon brain implantation. One solution consists of embedding the implant in a gelatin-based matrix, which is resorbable. In the case where nanostructures are present at the surface of the implant, it is crucial that the embedding matrix also preserves the nanostructures, which can be challenging considering the forces involved during the drying phase of gelatin. Here, the authors show that freestanding gallium phosphide nanowires coated with hafnium oxide (HfO2), titanium (Ti), and gold (Au) were preserved in a gelatin-glycerol embedding matrix with subsequent implantation in 1% agar, which is a model for brain implantation. (C) 2010 American Vacuum Society. [DOI: 10.1116/1.3498764]

Publishing year

2010

Language

English

Pages

6-16

Publication/Series

Journal of Vacuum Science and Technology B

Volume

28

Issue

6

Document type

Journal article

Publisher

American Institute of Physics (AIP)

Topic

  • Neurosciences

Status

Published

Project

  • Vävnadsreaktioner i nervsystemet efter elektrodimplantation

Research group

  • Neuronano Research Center (NRC)
  • Neural Interfaces
  • Neurophysiology

ISBN/ISSN/Other

  • ISSN: 1520-8567