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The role of leukotriene receptor signaling in inflammation and cancer

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Author

Summary, in English

Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT(1) receptor signaling pathway. In addition, we delineate how continuous CysLT(1) receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity.

Publishing year

2007

Language

English

Pages

1413-1421

Publication/Series

Scientific World Journal

Volume

7

Document type

Journal article

Publisher

Hindawi Limited

Topic

  • Cancer and Oncology

Keywords

  • CysLT(1) receptor
  • proliferation
  • leukotrienes
  • survival

Status

Published

Research group

  • Cell Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 2356-6140