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Cytogenetic findings in pediatric renal cell carcinoma

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Author

  • Maria Johansson Soller
  • Carl-Magnus Kullendorff
  • Albert N Békássy
  • Jan Alumets
  • Fredrik Mertens

Summary, in English

Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that are similar to their adult counterparts.

Publishing year

2007-02

Language

English

Pages

75-80

Publication/Series

Cancer Genetics and Cytogenetics

Volume

173

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology
  • Pediatrics
  • Medical Genetics

Keywords

  • Adolescent
  • Carcinoma, Papillary
  • Carcinoma, Renal Cell
  • Child
  • Chromosome Aberrations
  • Chromosome Banding
  • Humans
  • Karyotyping
  • Kidney Neoplasms
  • Ring Chromosomes
  • Tumor Cells, Cultured
  • Case Reports
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

ISBN/ISSN/Other

  • ISSN: 0165-4608