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Infectious Agents, the Contact System, and Innate Immunity

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Author

Summary, in English

The early host response to an infection is dependent on an efficient innate immune system. The human contact system once activated at a bacterial surface results in the induction of proinflammatory reactions and the release of antimicrobial peptides, However, under severe conditions its systemic activation A may evoke the generation of pathologic levels of kinins and a consumption of contact factors, which can both contribute to the progression of the disease and cause life-threatening complications. The present review aims to give an update on the role of the contact system in infectious diseases. (C) 2008 S. Karger GmbH, Freiburg i.Br.

Publishing year

2008

Language

English

Pages

60-70

Publication/Series

Progress and Challenges in Transfusion Medicine, Hemostasis, and Hemotherapy State of the Art 2008

Document type

Conference paper

Publisher

Karger

Topic

  • Infectious Medicine

Keywords

  • Contact system
  • Coagulation
  • Infectious diseases
  • Inflammation
  • immunity
  • Innate

Conference name

41st Congress of the German-Society-for-Transfusion-Medicine-and-Immunohematology/Interdiscip linary European-Society-for-Hemapheresis-and-Hemotherapy

Conference date

2008-09-16 - 2008-09-19

Status

Published

ISBN/ISSN/Other

  • ISBN: 978-3-8055-8659-7