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Plasma apolipoprotein M responses to statin and fibrate administration in type 2 diabetes mellitus

På svenska

Author

  • Paul J. W. H. Kappelle
  • Josefin Ahnström
  • Bert D. Dikkeschei
  • Rindert de Vries
  • Wim J. Sluiter
  • Bruce H. R. Wolffenbuttel
  • Arie van Tol
  • Lars Bo Nielsen
  • Björn Dahlbäck
  • Robin P. F. Dullaart

Summary, in English

Purpose: Plasma apolipoprotein M (apoM) is potentially anti-atherogenic, and has been found to be associated positively with plasma total, LDL and HDL cholesterol in humans. ApoM may, therefore, be intricately related to cholesterol metabolism. Here, we determined whether plasma apoM is affected by statin or fibrate administration in patients with diabetes mellitus. Methods: Fourteen type 2 diabetic patients participated in a placebo-controlled crossover study which included three 8-week treatment periods with simvastatin (40 mg daily), bezafibrate (400 mg daily), and their combination. Results: ApoM was decreased by 7% in response to simvastatin (P < 0.05 from baseline and placebo), and remained unchanged during bezafibrate and combined simvastatin + bezafibrate administration. Plasma apoM concentrations correlated positively with apoB-containing lipoprotein measures at baseline and during placebo (P < 0.02 to P < 0.001), but these relationships were lost during all lipid lowering treatment periods. Conclusions: This study suggests that, even though plasma apoM is lowered by statins, apoM metabolism is to a considerable extent independent of statin-and fibrate-affected pathways involved in cholesterol homeostasis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Publishing year

2010

Language

English

Pages

247-250

Publication/Series

Atherosclerosis

Volume

213

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • LDL
  • HDL cholesterol
  • Bezafibrate
  • Apolipoprotein M
  • Apolipoprotein B
  • cholesterol
  • Simvastatin
  • Type 2 diabetes

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1879-1484