Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Summary, in English

Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.

• Author: Isabel Goncalves; Eva Bengtsson; Helen M Colhoun; Angela C Shore; Carlo Palombo; Andrea Natali; Andreas Edsfeldt; Pontus Dunér; Gunilla Nordin Fredrikson; Harry Björkbacka; Gerd Östling; Kunihiko Aizawa; Francesco Casanova; Margaretha Persson; Kim Gooding; David Strain; Faisel Kahn; Helen C Looker; Fiona Adams; Jill Belch; Silvia Pinnoli; Elena Venturi; Michaela Kozakova; Li-Ming Gan; Volker Schnecke; Jan Nilsson
• Department/s: EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health; Cardiovascular Research - Translational Studies; Cardiovascular Research - Immunity and Atherosclerosis; Cardiovascular Research - Matrix and Inflammation in Atherosclerosis; Internal Medicine - Epidemiology
• Publishing year: 2015
• Language: English
• Pages: 1723-1731
• Publication/Series: Arteriosclerosis, Thrombosis and Vascular Biology
• Volume: 35
• Issue: 7
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25953645?dopt=Abstract; http://dx.doi.org/10.1161/ATVBAHA.115.305631
• Document type: Journal article
• Publisher: Lippincott Williams & Wilkins
• Topic: Cardiac and Cardiovascular Systems
• Status: Published
• Research group: Cardiovascular Research - Translational Studies; Cardiovascular Research - Immunity and Atherosclerosis; Cardiovascular Research - Matrix and Inflammation in Atherosclerosis; Internal Medicine - Epidemiology
• ISBN/ISSN/Other: ISSN: 1524-4636