Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.

Summary, in English

The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson's disease (PD) patients have shown efficacy (albeit not in all cases) and have paved the way for further development of cell replacement therapy strategies in PD. The preclinical work that led to these clinical trials used allografts of fetal VM tissue placed into 6-OHDA lesioned rats, while the patients received similar allografts under cover of immunosuppression in an α-synuclein disease state. Thus developing models that more faithfully replicate the clinical scenario would be a useful tool for the translation of such cell-based therapies to the clinic.

• Author: Anna Tamburrino; Madeline J Churchill; Oi Wan Wan; Yolanda Colino Sanguino; Rossana Ippolito; Sofie Bergstrand; Daniel Wolf; Niculin J Herz; Michelle D Sconce; Anders Björklund; Charles K Meshul; Mickael Decressac
• Department/s: Wallenberg Neuroscience Centre, Lund; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2015-12-14
• Language: English
• Publication/Series: Acta Neuropathologica Communications
• Volume: 3
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26666562?dopt=Abstract; http://dx.doi.org/10.1186/s40478-015-0263-6
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Neurosciences
• Status: Published
• ISBN/ISSN/Other: ISSN: 2051-5960