The anti-angiogenic peptide anginex greatly enhances Galectin-1 binding affinity for glycoproteins
Author
Summary, in English
Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred-to thousand-fold higher affinity. Anginex also interacts with galectin-2,-7,-8N, and-9N but not with galectin-3,-4, or-9C.
Department/s
- Division of Microbiology, Immunology and Glycobiology - MIG
- Centre for Analysis and Synthesis
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2011
Language
English
Pages
13801-13804
Publication/Series
Journal of Biological Chemistry
Volume
286
Issue
16
Links
Document type
Journal article
Publisher
American Society for Biochemistry and Molecular Biology
Topic
- Immunology in the medical area
- Microbiology in the medical area
Status
Published
ISBN/ISSN/Other
- ISSN: 1083-351X