The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

The gene of the protease inhibitor SKALP/elafin is a member of the REST gene family

På svenska

Author

Summary, in English

Members of the REST gene family characteristically have a transcription unit consisting of three exons. The first and the last exon are conserved among members, while the second exon--encoding almost all of the mature protein--differs considerably. The so far known REST genes are highly, and almost exclusively, expressed in the seminal vesicles. By sequence analysis we have now identified the gene for the protease inhibitor SKALP/elafin as a new member of the REST gene family. The protein is expressed in the epidermis and serves, like the product of several REST genes, as substrate for transglutaminase. We have also found what seems to be a locus encompassing both transglutaminases and REST genes centered around the region q12 on the human chromosome 20, raising the question whether the enzymes and substrates have evolved in parallel.

Publishing year

1996

Language

English

Pages

7-323

Publication/Series

Biochem Biophys Res Commun

Volume

221

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Medicinal Chemistry

Keywords

  • Proteins/*genetics
  • *Multigene Family
  • Molecular Sequence Data
  • Humans
  • Complementary
  • DNA
  • Animals
  • Base Sequence
  • Research Support
  • Non-U.S. Gov't
  • Sequence Homology
  • Nucleic Acid
  • Serine Proteinase Inhibitors/*genetics

Status

Published

Research group

  • Clinical Chemistry, Malmö