Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma.

Summary, in English

The toll-like receptors, TLR5 and TLR7, have recently been proposed in asthma immunopathogenesis. While supporting data come from animal or in vitro studies, little is known about TLR5 and TLR7 expression in human asthmatic airways.

• Author: Medya Shikhagaie; Cecilia Andersson; Michiko Mori; I Kortekaas Krohn; Anders Bergqvist; R Dahl; Eva Ekblad; H J Hoffmann; Leif Bjermer; Jonas Erjefält
• Department/s: Airway Inflammation and Immunology; Neurogastroenterology; Respiratory Medicine, Allergology, and Palliative Medicine; EpiHealth: Epidemiology for Health
• Publishing year: 2014
• Language: English
• Pages: 184-196
• Publication/Series: Clinical and Experimental Allergy
• Volume: 44
• Issue: 2
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24447081?dopt=Abstract; http://dx.doi.org/10.1111/cea.12176
• Document type: Journal article
• Publisher: Wiley
• Topic: Immunology in the medical area; Respiratory Medicine and Allergy; Gastroenterology and Hepatology
• Status: Published
• Research group: Airway Inflammation and Immunology; Neurogastroenterology
• ISBN/ISSN/Other: ISSN: 1365-2222