Enzymatic characterization of lipid-based drug delivery systems
Author
Summary, in English
The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.
Department/s
Publishing year
2005
Language
English
Pages
328-332
Publication/Series
International Journal of Pharmaceutics
Volume
298
Issue
2
Document type
Journal article
Publisher
Elsevier
Topic
- Food Engineering
Keywords
- Self-microemulsifying drug delivery system
- Lipolysis
- Probucol
- Halofantrine
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-3476