Treatment with pioglitazone induced significant, reversible mitral regurgitation
Author
Summary, in English
There has in recent years been great concern about possible cardiac side effects of thiazolidinediones ( TZDs). We present a case-report of a 60 year-old male who developed significant mitral regurgitation during six months treatment with pioglitazone in parallel with laboratory indications of fluid retention. Echocardiography six months after discontinuation of medication showed regression of mitral regurgitation and the laboratory parameters were also normalized. It is noteworthy that six months treatment with pioglitazone could induce significant valve dysfunction, which was reversible, and this underlines the importance of carefully monitoring patients when placing them on treatment with TZDs.
Publishing year
2008
Language
English
Publication/Series
Cardiovascular Diabetology
Volume
7
Issue
12
Document type
Journal article
Publisher
BioMed Central (BMC)
Topic
- Endocrinology and Diabetes
- Radiology, Nuclear Medicine and Medical Imaging
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
- Clinical Physiology, Malmö
ISBN/ISSN/Other
- ISSN: 1475-2840