Versican in inflammation and tissue remodelling: the impact on lung disorders.

Summary, in English

Versican is a proteoglycan that has many different roles in tissue homeostasis and inflammation. The biochemical structure is comprised of four different types of the core protein with attached glycosaminoglycans that can be sulphated to various extents and has the capacity to regulate differentiation of different cell types, migration, cell adhesion, proliferation, tissue stabilization and inflammation. Versican's regulatory properties are of importance during both homeostasis and changes that lead to disease progression. The glycosaminoglycans that are attached to the core protein are of the chondroitin sulfate/dermatan sulfate type and are known to be important in inflammation through interactions with cytokines and growth factors. For a more complex understanding of versican it is of importance to study the tissue niche, where the wound healing process in both healthy and diseased conditions take place. In previous studies our group has identified changes in the amount of the multifaceted versican in chronic lung disorders such as asthma, chronic obstructive pulmonary disease and bronchiolitis obliterans syndrome, which could be a result of pathologic, transforming growth factor β driven, on-going remodelling processes. Reversely, the context of versican in its niche is of great importance since versican has been reported to have a beneficial role in other contexts e.g. emphysema. Here we explore the vast mechanisms of versican in healthy lung and in lung disorders.

• Author: Annika Andersson Sjöland; Oskar Hallgren; Sara Rolandsson Enes; Maria Weitoft; Emil Tykesson; Anna-Karin Larsson Callerfelt; Kristina Rydell-Törmänen; Leif Bjermer; Anders Malmström; Jenny C Karlsson; Gunilla Westergren-Thorsson
• Department/s: Lung Biology; Respiratory Medicine, Allergology, and Palliative Medicine; Matrix Biology; EpiHealth: Epidemiology for Health
• Publishing year: 2015
• Language: English
• Pages: 243-251
• Publication/Series: Glycobiology
• Volume: 25
• Issue: 3
• Full text: - 23 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25371494?dopt=Abstract; http://dx.doi.org/10.1093/glycob/cwu120
• Document type: Journal article review
• Publisher: Oxford University Press
• Topic: Biochemistry and Molecular Biology
• Status: Published
• Research group: Lung Biology; Matrix Biology
• ISBN/ISSN/Other: ISSN: 1460-2423