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Peripheral serotonergic markers in patients with suicidal behavior

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Author

Summary, in English

Peripheral serotonergic parameters were studied in 17 patients with a history of suicidal behavior and in 17 age- and sex-matched healthy controls. Serotonin2 receptor function in platelets, measured as serotonin-induced [32P]phosphatidylinositol 4,5-bisphosphate hydrolysis, was significantly higher in patients than in age- and sex-matched controls. Increased serotonin2 receptor transduction was not correlated to psychiatric diagnosis, drug treatment or a history of violent suicide attempt. Monoamine oxidase activity was lower in platelets from patients with a history of suicidal behavior than in controls. In addition, whole blood serotonin was analyzed but no significant alterations were found in blood from patients.

Publishing year

1991

Language

English

Pages

503-510

Publication/Series

European Neuropsychopharmacology

Volume

1

Issue

4

Document type

Journal article

Publisher

Elsevier

Topic

  • Psychiatry
  • Pharmacology and Toxicology

Keywords

  • Suicide
  • Phosphatidylinositol 4
  • 5-bisphosphate
  • Serotonin
  • Serotonin2 receptors
  • Monoamine oxidase
  • Phospholipase C
  • Platelets
  • Blood

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1873-7862