Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice with Severe Acute Pancreatitis.

Summary, in English

Neutrophils are involved in development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported contribute to organ dysfunction in patients with infectious diseases. We investigated whether NETs contribute to development of AP in mice.

• Author: Mohammed Merza; Hannes Hartman Magnusson; Milladur Rahman; Rundk Hwaiz; Enming Zhang; Erik Renström; Lingtao Luo; Matthias Mörgelin; Sara Regnér; Henrik Thorlacius
• Department/s: Surgery; Diabetes - Islet Patophysiology; Infection Medicine (BMC); EXODIAB: Excellence of Diabetes Research in Sweden
• Publishing year: 2015
• Language: English
• Pages: 1920-1920
• Publication/Series: Gastroenterology
• Volume: 149
• Issue: 7
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26302488?dopt=Abstract; http://dx.doi.org/10.1053/j.gastro.2015.08.026
• Document type: Journal article
• Publisher: Elsevier
• Topic: Gastroenterology and Hepatology
• Status: Published
• Research group: Surgery; Diabetes - Islet Patophysiology
• ISBN/ISSN/Other: ISSN: 1528-0012