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New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

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Author

  • Alexandra Fagerström
  • Mikael Nilsson
  • Ulf Berg
  • Roland Isaksson

Summary, in English

Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.

Publishing year

2006

Language

English

Pages

3067-3076

Publication/Series

Organic and Biomolecular Chemistry

Volume

4

Issue

16

Document type

Journal article

Publisher

Royal Society of Chemistry

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 1477-0539