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Experimental hyperthyroidism in man: effects on plasma lipoproteins, lipoprotein lipase and hepatic lipase

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Author

Summary, in English

We have studied the effects of triiodothyronine administration (20-40 micrograms three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations. Hepatic lipase activity in post-heparin plasma rose by 46 +/- 25% (p less than 0.025), whereas the activity of lipoprotein lipase did not change significantly. Plasma cholesterol concentrations decreased by about 20% (p less than 0.025), whereas there was no change in plasma triglyceride levels. The fall in plasma cholesterol could be accounted for by a reduction of HDL cholesterol (-11%, p less than 0.025) as well as LDL cholesterol (-27%, p less than 0.025). The data emphasize the role of hepatic lipase in the lipoprotein alterations associated with thyroid dysfunction.

Publishing year

1983

Language

English

Pages

449-452

Publication/Series

Hormone and Metabolic Research

Volume

15

Issue

9

Document type

Journal article

Publisher

Georg Thieme Verlag

Topic

  • Medicinal Chemistry
  • Other Clinical Medicine
  • Pharmacology and Toxicology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1439-4286