Count rate characteristics and image distortion in preclinical PET systems during intratherapeutic radiopharmaceutical therapy imaging
Author
Summary, in English
Positron emission tomography (PET) may provide important information on the therapeutic response of radiopharmaceutical therapy (RPT) during therapy. The radiation emission from the RPT radionuclide may disturb the coincidence detection and impair the image resolution. In this study we tested the feasibility to perform intratherapeutic PET on three preclinical PET systems.
METHODS: Using (22)Na point sources and phantoms filled with (18)F, and a phantom filled with either (99m)Tc or (177)Lu, the coincidence count rate and the spatial resolution when both a PET and a therapeutic radionuclide were present in the PET camera, were evaluated. (99m)Tc was used as a substitute for a generic therapeutic radioisotope, since it has a suitable half-life and is easy obtainable.
RESULTS: High activities of (99m)Tc deteriorated the coincidence count rate from the (18)F-filled phantom with a (22)Na point source on all three systems evaluated. One of the systems could to a high degree correct the count rate with its dead time correction. The spatial resolution was degraded at high activities of (99m)Tc for all systems. On one of the systems (177)Lu increased the coincidence count rate and slightly affected the spatial resolution. The results for high activities of (177)Lu were similar to those for (99m)Tc.
CONCLUSION: Intratherapeutic imaging might be a feasible method to study RPT treatment response. However, some sensitive preclinical PET systems, unable to handle high count rates, suffer count losses and may also introduce image artifacts.
Department/s
- Tumor microenvironment
- Atomic Physics
- Medical Radiation Physics, Lund
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2016-07-28
Language
English
Pages
1964-1970
Publication/Series
Journal of Nuclear Medicine
Volume
57
Issue
12
Document type
Journal article
Publisher
Society of Nuclear Medicine
Topic
- Radiology, Nuclear Medicine and Medical Imaging
- Other Physics Topics
Status
Published
ISBN/ISSN/Other
- ISSN: 0161-5505