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Natural Pseudoguaianolides Prepared from Damsin

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Author

  • Rodrigo Villagomez
  • M. Quiroz
  • A. Tito
  • Olov Sterner
  • G. R. Almanza

Summary, in English

Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3 alpha-hydroxydamsin (4), 3 alpha-acetoxydamsin (5), and 11 beta,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.

Publishing year

2015

Language

English

Pages

675-680

Publication/Series

Chemistry of Natural Compounds

Volume

51

Issue

4

Document type

Journal article

Publisher

Springer

Topic

  • Organic Chemistry

Keywords

  • sesquiterpene lactones
  • pseudoguaianolides
  • semi-synthesis
  • ambrosanolides
  • derivatization
  • damsin

Status

Published

ISBN/ISSN/Other

  • ISSN: 0009-3130